Effects of phospholipids on antiganglioside antibody reactivity in GBS

Autor(es): Hirakawa Minako,Morita Daiji,Tsuji Shoji,Kusunoki Susumu

Resumo: Serum antibody activities to mixtures of a ganglioside and various phospholipids were compared with those to a ganglioside alone in 30 anti-GM1 IgG-positive GBS patients and 30 anti-GQ1b IgG-positive Miller Fisher syndrome (MFS) patients. Anti-GM1-positive sera had higher antibody reactivities against a mixture of GM1 and several phospholipids including PA, PI and PS, than against GM1 alone. In contrast, in case of anti-GQ1b antibody, no phospholipid provided significant enhancement. Sphingomyelin provided decrease of the activity for both anti-GM1 and anti-GQ1b IgG. The effects of phospholipids must be considered to determine the pathogenetic role of antiganglioside antibodies in GBS and MFS.

Palavras-Chave: GBS; Antiganglioside antibody; Phospholipids

Imprenta: Journal of Neuroimmunology, v. 159, n. 1-2, p. 129-132, 2005

Identificador do objeto digital: 10.1016/j.jneuroim.2004.09.018

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Molecular Structure ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2005