Autor(es): Spaans Frank,Vredeveld Jan-Willem,Morré Humphrey H E,Jacobs Bart C,De Baets Marc H

Resumo: In nine patients with Guillain-Barré syndrome (GBS), stimulation single-fiber electromyography (SFEMG) and serological studies were performed in the acute stage of the illness. Increased jitter and intermittent blocking of muscle fiber action potentials occurred to a varying degree in all patients. Five patients had elevated titers of antiganglioside antibodies. The most remarkable EMG phenomenon was the occurrence in all patients of impulse blocking at normal or slightly increased jitter. The assumption that this phenomenon was due to an axolemmal dysfunction was confirmed by the occurrence in two patients of concomitant blocking of two muscle fiber action potentials at strictly normal jitter values. In one patient this sign of axonal dysfunction was demonstrated with SFEMG at voluntary activation. In another patient, concomitant blocking was associated with greatly increased but completely independent jitter of both components. The results of this study show that both a disorder of neuromuscular transmission and an axolemmal dysfunction play a role in the pathophysiology of GBS.

Palavras-Chave: Axonal blocking; Guillain-Barre syndrome; Neuromuscular transmission; Serological studies; Single-?ber EMG

Imprenta: Muscle & Nerve, v. 27, n. 4, p. 426-434, 2003

Identificador do objeto digital: 10.1002/mus.10334

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Serological diagnosis ; Guillain-Barre Syndrome - Transmission ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2003