Autor(es): Li Q,Wang Z,Zhu D,Xu M,Chen X,Peng D,Iwata Y,Xie P

Resumo: Borna disease virus (BDV) is a neurotropic RNA virus that is known to cause neurological disturbances in various animal species, potentially even humans. However, the association between BDV infection and human neurological disorders remains unclear. Between August 2005 and March 2006, 65 patients with neurological disorders were enrolled into our study. The presence of BDV p24 RNA from peripheral blood mononuclear cells (PBMCs) was investigated by using nested reverse transcriptase PCR (RT-PCR) assay. Borna disease virus p24 RNA was detected from PBMCs in six patients with viral encephalitis by using nested RT-PCR assay. However, BDV p24 RNA was not detected in patients with multiple sclerosis or peripheral nerve diseases. There might be possible associations between BDV infection and human viral encephalitis.

Palavras-Chave: Borna disease virus(BDV); Nested RT-PCR; Peripheral blood mono-nuclear cells (PBMCs)

Imprenta: European Journal of Neurology, v. 16, n. 3, p. 399-403, 2009

Identificador do objeto digital: 10.1111/j.1468-1331.2008.02516.x

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - RNA ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - PCR detection ; Guillain-Barre Syndrome - RT-PCR ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2009

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