Decreased intrathecal synthesis of prostaglandin D2 synthase in the cerebrospinal fluid of patients with acute inflammatory demyelinating polyneuropathy
Autor(es): Huang Yen-Chu,Lyu Rong-Kuo,Tseng Mu-Yun,Chang Hong-Shiu,Hsu Wen-Chuin,Kuo Hung-Chou,Chu Chun-Che,Wu Yih-Ru,Ro Long-Sun,Huang Chin-Chang,Chen Chiung-Mei
Resumo: Prostaglandin D(2) synthase (PGDS) is the most abundant brain protein in cerebrospinal fluid (CSF) and is tied closely with inflammatory processes. This study investigated whether CSF PGDS levels in patients with acute inflammatory demyelinating polyneuropathy (AIDP) are altered. The results suggest that PGDS concentration is significantly increased in the CSF of AIDP patients compared with the control patients (p<0.05) due to a blood-CSF barrier dysfunction, whereas the intrathecal synthesis of PGDS, reflected by the CSF PGDS/albumin ratio, is significantly decreased in AIDP compared with the control group (p<0.05). The changes of CSF PGDS/albumin ratio are only observed in AIDP patients, but not in Miller Fisher Syndrome (MFS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), or multiple sclerosis (MS) patients.
Palavras-Chave: Prostaglandin D2 synthase; Cerebrospinal fluid; Guillain-Barré syndrome; Acute inflammatory demyelinating polyneuropathy
Imprenta: Journal of Neuroimmunology, v. 206, n. 1-2, p. 100-105, 2009
Identificador do objeto digital: 10.1016/j.jneuroim.2008.10.011
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Protein synthesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Public health
Data de publicação: 2009
