Autor(es): Assir Muhammad Zaman Khan,Ahmad Hafiz Ijaz,Masood Muhammad Adnan,Kamran Umair,Yusuf Noshin Wasim

Resumo: We conducted this study to review deaths due to dengue fever (DF) during a large outbreak of DF in Lahore, Pakistan. We reviewed deaths due to DF at Jinnah Hospital Lahore between August and November 2011. Clinical and laboratory data were abstracted. The 2011 World Health Organization Regional Office for South-East Asia (WHO SEARO) guidelines were used to classify the disease. Out of 128,634 probable DF patients who visited the outpatient department, 2313 patients were hospitalized; 1699 (73.3%) were male. RT-PCR was positive in 92 of 114 hospitalized patients (DENV-2 in 91 patients and DENV-3 in 1 patient). Sixty dengue-related deaths were reported; 41 (68.3%) were male. The mean age (± standard deviation) was 44 (± 20.5) y. The diagnosis at the time of presentation was DF in 5 (8.3%), dengue haemorrhagic fever without shock in 16 (26.6%), dengue shock syndrome in 20 (33%), and expanded dengue syndrome in 19 (31.7%) patients. Expanded dengue syndrome included encephalopathy in 12 (20%) patients, intracerebral bleed in 3 (5%), multiorgan failure in 3 (5%), and Guillain-Barré syndrome in 1 (1.6%). Twenty-nine (48.3%) patients had at least 1 comorbidity. Dengue shock syndrome and expanded dengue syndrome were the most common causes of death.

Palavras-Chave: Dengue fever; Dengue haemorrhagic fever; Dengue shock syndrome; Expanded dengue syndrome; Death rate; Pakistan

Imprenta: Scandinavian Journal of Infectious Diseases, v. 46, n. 4, p. 303-309, 2014

Identificador do objeto digital: 10.3109/00365548.2013.877155

Descritores: Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - RT-PCR ; Guillain-Barre Syndrome - Dengue ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2014

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