Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barré syndrome

Autor(es): Jacobs B C,van Doorn P A,Groeneveld J H,Tio-Gillen A P,van der Meché F G

Resumo: To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barré syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barré syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barré syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barré syndrome associated with CMV.

Palavras-Chave: Guillain-Barre syndrome; Anti-GM2 antibodies; Cytomegalovirus

Imprenta: Journal of Neurology, Neurosurgery, and Psychiatry, v. 62, n. 6, p. 641-643, 1997

Identificador do objeto digital: 10.1136/jnnp.62.6.641

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Immunology

Data de publicação: 1997