Cytokine pattern in the cerebrospinal fluid from patients with GBS and CIDP

Autor(es): Sivieri S,Ferrarini A M,Lolli F,Matà S,Pinto F,Tavolato B,Gallo P

Resumo: Macrophage-colony stimulating factor (M-CSF) and, less frequently, IL-1 beta and IL-6 were detected in the cerebrospinal fluid (SF) from Guillain-Barré syndrome (GBS) patients. IL-1 alpha, IL-2, IL-10, TNF alpha, and IFN gamma were not found. Detectable cytokine levels were not observed in chronic inflammatory demyelinating polyneuropathy (CIDP) SF nor in any of the sera studied. These findings suggest a prominent intrathecal activation of cells of the monocyte/macrophage lineage (Mø) in GBS, and further support the hypothesis of a crucial role for Mø in GBS immunopathology.

Palavras-Chave: Guillain-Barré syndrome; Cerebrospinal fluid; Cytokines; Macrophages

Imprenta: Journal of the Neurological Sciences, v. 147, n. 1, p. 93-95, 1997

Identificador do objeto digital: 10.1016/S0022-510X(96)00319-X

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunopathology

Data de publicação: 1997