CSF neurofilament levels: a potential prognostic marker in Guillain-Barré syndrome
Autor(es): Petzold A,Hinds N,Murray N M F,Hirsch N P,Grant D,Keir G,Thompson E J,Reilly M M
Resumo: Long-term morbidity from Guillain-Barré syndrome (GBS) is caused by axonal damage. This prospective study demonstrated that neurofilaments (NfHs), a biomarker for axonal damage, were of prognostic value in GBS. CSF NfH levels correlated with the F score and Medical Research Council summed score and were higher in patients with neurophysiologic evidence of axonal degeneration compared to those without. Pathologically high CSF NfH levels (>0.73 ng/mL) predicted worse motor and functional outcome.
Imprenta: Neurology, v. 67, n. 6, p. 1071-1073, 2006
Identificador do objeto digital: 10.1212/01.wnl.0000237334.69665.92
Descritores: Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Public health
Data de publicação: 2006
