CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies
Autor(es): Nishino S,Kanbayashi T,Fujiki N,Uchino M,Ripley B,Watanabe M,Lammers G J,Ishiguro H,Shoji S,Nishida Y,Overeem S,Toyoshima I,Yoshida Y,Shimizu T,Taheri S,Mignot E
Resumo: CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.
Imprenta: Neurology, v. 61, n. 6, p. 823-825, 2003
Identificador do objeto digital: 10.1212/01.WNL.0000081049.14098.50
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins
Data de publicação: 2003
