Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome
Autor(es): Ang C W,Tio-Gillen A P,Groen J,Herbrink P,Jacobs B C,Van Koningsveld R,Osterhaus A D M E,Van der Meché F G A,van Doorn P A
Resumo: Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with MP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP.
Palavras-Chave: Molecular mimicry; Neuropathy; Mycoplasma pneumoniae
Imprenta: Journal of Neuroimmunology, v. 130, n. 1-2, p. 179-183, 2002
Identificador do objeto digital: 10.1016/S0165-5728(02)00209-6
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Infectious diseases ; Guillain-Barre Syndrome - Molecular screening ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2002
