Could autoimmunity be induced by vaccination?
Autor(es): Salemi Simonetta,D'Amelio Raffaele
Resumo: Autoimmune reactions to vaccinations may rarely be induced in predisposed individuals by molecular mimicry or bystander activation mechanisms. Autoimmune reactions reliably considered vaccine-associated, include Guillain-Barré syndrome after 1976 swine influenza vaccine, immune thrombocytopenic purpura after measles/mumps/rubella vaccine, and myopericarditis after smallpox vaccination, whereas the suspected association between hepatitis B vaccine and multiple sclerosis has not been further confirmed, even though it has been recently reconsidered, and the one between childhood immunization and type 1 diabetes seems by now to be definitively gone down. Larger epidemiological studies are needed to obtain more reliable data in most suggested associations.
Palavras-Chave: Vaccinations; Autoimmune diseases; Systemic lupus erythematosus; Rheumatoid arthritis; Multiple sclerosis; Insulin-dependent diabetes mellitus; Vasculitides
Imprenta: International Reviews of Immunology, v. 29, n. 3, p. 247-269, 2010
Identificador do objeto digital: 10.3109/08830181003746304
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Autoimmunity ; Guillain-Barre Syndrome - Infectious diseases ; Guillain-Barre Syndrome - Vaccine ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health
Data de publicação: 2010
