Correlation of matrix metalloproteinases-2 and -9 with proinflammatory cytokines in Guillain-Barré syndrome

Autor(es): Nyati Kishan K,Prasad Kashi N,Verma Avantika,Paliwal Vimal K

Resumo: The role of matrix metalloproteinases (MMPs) and cytokines in the pathogenesis of Guillain-Barré syndrome (GBS) largely remains unknown. We studied the role of MMP-2, MMP-9, tumor necrosis factor-? (TNF-?), and interleukin-1? (IL-1?) in disease progression and recovery of patients with GBS. Sixty-five patients with GBS and 68 healthy controls were enrolled in the study. Serum levels of MMP-2, MMP-9, TNF-?, and IL-1? were analyzed by ELISA, and activities of MMPs were measured by zymography. Expression of MMP-9, TNF-?, and IL-1? was higher in the progressive phase and lower in the recovery phase of GBS than in controls. A positive correlation of MMP-2 with IL-1? and MMP-9 with TNF-? and IL-1? was observed with progressive-phase GBS. The study shows that up-regulation of MMP-9 along with proinflammatory cytokines (TNF-? and IL-1?) in the early course appears to be associated with immune-mediated disease progression resulting from inflammation in the peripheral nervous system, whereas, during the later phase, down-regulation of MMP-9 and proinflammatory cytokines is implicated in recovery from the disease.

Palavras-Chave: Guillain-Barre´syndrome; Demyelinating neuropathy; Blood-nerve barrier; In?ammation; MMP-2; MMP-9

Imprenta: Journal of Neuroscience Research, v. 88, n. 16, p. 3540-3546, 2010

Identificador do objeto digital: 10.1002/jnr.22514

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Inflammation ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2010