Autor(es): Huang Shuo,Li Lei,Liang Songlan,Wang Weizhi

Resumo: CD4(+)CD25(-) T cells from 25 Guillain-Barré syndrome (GBS) patients were stimulated by IFN-gamma to generate the induced CD4(+)CD25(+) regulatory T cells (iTregs). Then, their phenotypical and functional characterizations were analyzed. Results show that iTregs can be generated from CD4(+)CD25(-) T cells in GBS patients by IFN-gamma in the presence of activating anti-CD3 and anti-CD28 antibodies in vitro. When CD4(+)CD25(-) T cells are stimulated by 40ng/ml IFN-gamma for 3days, the ratio of conversion is the highest under this condition and iTregs are similar to naturally occurring CD4(+)CD25(+) regulatory T cells of healthy donors phenotypically and functionally.

Palavras-Chave: Guillain-Barré syndrome (GBS); IFN-?; CD4+CD25? T cells; Induced CD4+CD25+ regulatory T cells (iTregs); CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs)

Imprenta: Journal of Neuroimmunology, v. 217, n. 1-2, p. 80-84, 2009

Identificador do objeto digital: 10.1016/j.jneuroim.2009.10.001

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2009