Congenital Guillain-Barré syndrome associated with maternal inflammatory bowel disease is responsive to intravenous immunoglobulin
Autor(es): Bamford Nigel S,Trojaborg Werner,Sherbany Ariel A,De Vivo Darryl C
Resumo: A 34-week floppy preterm infant born to a mother with acute ulcerative colitis presented with a progressive reduction in spontaneous limb movements, severe generalized hypotonia, areflexia, autonomic dysfunction and respiratory failure. Electromyography revealed pronounced denervation activity and markedly slow nerve conduction velocity (3 m/s) with evidence of conduction block. These findings indicated demyelination with additional axonal features. The infant was diagnosed with congenital Guillain-Barré syndrome, was treated with intravenous immunoglobulin and showed clinical improvement within 48 hours of treatment. The relationship between inflammatory bowel syndrome and inflammatory demyelinating polyneuropathy is discussed.
Palavras-Chave: Neonate; Guillain-Barre syndrome; Floppy infant syndrome; Ulcerative colitis; Inflammatory bowel disease; Intravenous Immunoglobulin
Imprenta: European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, v. 6, n. 2, p. 115-119, 2002
Identificador do objeto digital: 10.1053/ejpn.2002.0557
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Clinical examination ; Guillain-Barre Syndrome - Public health
Data de publicação: 2002
