Complete recovery of an aged patient with Guillain-Barré syndrome associated with multiple IgM anti-ganglioside antibodies

Autor(es): Furiya Yoshiko,Hirano Makito,Kusunoki Susumu,Ueda Masami,Sugie Kazuma,Nishiwaki Tomohisa,Ueno Satoshi

Resumo: In this report we describe a 72-year-old woman who had cytomegalovirus infection-related Guillain-Barré syndrome (GBS) associated with multiple immunoglobulin M (IgM) anti-ganglioside antibodies. She became tetraplegic with respiratory failure, but recovered completely after intravenous immunoglobulin therapy and plasmapheresis. The serum contained high-titer IgM antibody activities to several gangliosides with disialosyl residues (GD1b, GD3, GT1b, GQ1b, and GT1a) and GD1a. These antibodies are often found in sera from patients with chronic sensory ataxic neuropathy, but they occur rarely in GBS.

Palavras-Chave: Anti-GD1a IgM antibody; Anti-disialosyl ganglioside IgM anti-body; Cytomegalovirus; Guillain-Barre syndrome

Imprenta: Muscle & Nerve, v. 38, n. 6, p. 1630-1633, 2008

Identificador do objeto digital: 10.1002/mus.21131

Descritores: Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2008