Complement activation by anti-GQ1b antibodies in Fisher syndrome and its variants

Autor(es): Yuki Nobuhiro,Hirata Koichi

Resumo: IgG anti-GQ1b antibodies are associated with Fisher syndrome (FS) as well as with its more and less extensive variants, Bickerstaff brainstem encephalitis and acute ophthalmoparesis. Passive transfer experiments provide evidence that anti-ganglioside antibodies and complement are pathogenic in the development of FS. In the current in vitro study, we could not demonstrate the association of complement activation with disease extension.

Palavras-Chave: Anti-GQ1b antibody; Bickerstaff brainstem encephalitis; Complement; Fisher syndrome

Imprenta: Journal of Neuroimmunology, v. 258, n. 1-2, p. 100-101, 2013

Identificador do objeto digital: 10.1016/j.jneuroim.2013.02.011

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2013