Clinical significance of antibodies against peripheral nerve tissue in inflammatory polyneuropathy
Autor(es): van Doorn P A,Brand A,Vermeulen M
Resumo: With the use of a mixed hemagglutination test (MHT), circulating antibodies against human peripheral nerve tissue (PNT) were found in 22 of 38 patients with Guillain-Barré syndrome (GBS) or chronic relapsing demyelinating inflammatory polyneuropathy (CR-DIP). The antibodies were found in only 1 of 34 patients with polyneuropathy of other origin, and in 3 of 32 patients without polyneuropathy. The presence of antibodies was related to response to intravenous gamma globulin treatment in CR-DIP patients. Antibodies against PNT may be pathogenic.
Imprenta: Neurology, v. 37, n. 11, p. 1798-1802, 1987
Identificador do objeto digital: 10.1212/WNL.37.11.1798
Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Serology ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1987
