Clinical features in Guillain-Barré syndrome with anti-Gal-C antibody

Autor(es): Samukawa Makoto,Hamada Yukihiro,Kuwahara Motoi,Takada Kazuo,Hirano Makito,Mitsui Yoshiyuki,Sonoo Masahiro,Kusunoki Susumu,

Resumo: Guillain-Barré syndrome (GBS) has often been associated with antibodies to glycolipids, such as galactocerebroside (Gal-C), a component of myelin. Whether patients who have GBS with anti-Gal-C antibody (Gal-C-GBS) more often have demyelinating neuropathy or axonal neuropathy remains controversial. Their clinical features have also been unestablished. We enrolled 47 patients with Gal-C-GBS. Their clinical and electrophysiological data were retrospectively reviewed and compared to 119 patients with GBS without anti-Gal-C antibody (non-Gal-C-GBS). Demyelinating polyneuropathy occurred 4 times more frequently than axonal polyneuropathy in patients with Gal-C-GBS, but without statistical significance compared to patients with non-Gal-C-GBS (2.2:1). Patients with Gal-C-GBS had more frequent sensory deficits, autonomic involvements, and antecedent Mycoplasma pneumoniae (MP) infection than patients with non-Gal-C-GBS. This is the largest study clarifying the clinical and electrophysiological findings that more frequent sensory deficits, autonomic involvements, and antecedent MP infection are associated with Gal-C-GBS.

Palavras-Chave: Anti-glycolipid antibody; Axonal neuropathy; Demyelinating neuropathy; Electrophysiological study; Galactocerebroside; Guillain-Barré syndrome; Mycoplasma pneumoniae

Imprenta: Journal of the Neurological Sciences, v. 337, n. 1-2, p. 55-60, 2014

Identificador do objeto digital: 10.1016/j.jns.2013.11.016

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2014