Chronic inflammatory demyelinating polyneuropathy responsive to mycophenolate mofetil therapy

Autor(es): Bedi Gurdesh,Brown Andrew,Tong Tao,Sharma Khema R

Resumo: To evaluate the efficacy of mycophenolate mofetil (MMF) in chronic inflammatory demyelinating polyneuropathy (CIDP). Evidence is growing that MMF is effective as an immunomodulatory drug in neuromuscular diseases. A database of 184 patients with CIDP was analysed to obtain clinical, laboratory and electrophysiological information for patients with CIDP treated with MMF. Eight patients, who met the inclusion criteria, received MMF (mean dose 2 g/day; median duration 15.2 months). The average Neuropathy Impairment Score of the eight patients improved from baseline (72.3+/-35) after initiation of MMF therapy (37.8+/-37; p<0.001). Six of these eight patients were either able to stop concomitant medications (corticosteroid, intravenous immunoglobulin) or reduce their doses and frequency by > or = 50%. Our pilot data suggest that MMF appears to be an effective therapy for patients with naive or refractory CIDP, and further controlled studies are warranted for their confirmation.

Imprenta: Journal of Neurology, Neurosurgery, and Psychiatry, v. 81, n. 6, p. 634-636, 2010

Identificador do objeto digital: 10.1136/jnnp.2009.177576

Descritores: Guillain-Barre Syndrome - Public health

Data de publicação: 2010