Autor(es): Lolli F,Matá S,Baruffi M C,Amaducci L

Resumo: We studied, with sensitive ELISAs, the anti-cardiolipin antibodies of the G, A, and M classes in the cerebrospinal fluid (CSF) and serum of 179 neurological patients. The CSF and serum of 2 systemic lupus erythematosus (SLE) patients presented IgG anti-cardiolipin antibodies in corresponding levels. Anti-cardiolipin antibodies were produced within the central nervous system in neurosyphilis (A and M classes), in some patients affected by multiple sclerosis (G or M class), in two cases of Guillain-Barré syndrome (G and A classes), and in one AIDS patient (G class). The CSF anti-cardiolipin antibodies detected in our study suggest a local immune reaction against brain phospholipids in SLE and in human demyelinating disorders.

Imprenta: Clinical Immunology and Immunopathology, v. 59, n. 2, p. 314-321, 1991

Identificador do objeto digital: 10.1016/0090-1229(91)90027-8

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 1991

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