Autor(es): Yuki Nobuhiro

Resumo: Molecular mimicry of microbial components by self components is thought to be the mechanism that accounts for the antigen and tissue specificity of immune responses in post-infectious autoimmune diseases. Little direct evidence exists, and research in this area has focused principally on T cell mediated anti-peptide responses, rather than on humoral responses to carbohydrate structures. Guillain-Barré syndrome, the most frequent cause of acute neuromuscular paralysis, sometimes occurs after Campylobacter jejuni enteritis. Recent studies have revealed that carbohydrate mimicry of the bacterial lipo-oligosaccharide by the human ganglioside is an important cause of the syndrome. This new concept that carbohydrate mimicry can cause an autoimmune disease provides a clue to inducing the resolution of pathogenesis of other immune-mediated diseases.

Imprenta: Current Opinion in Immunology, v. 17, n. 6, p. 577-582, 2005

Identificador do objeto digital: 10.1016/j.coi.2005.09.004

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Infectious diseases ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2005

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