Campylobacter jejuni targets immunoglobulin-like receptor LMIR5.
Autor(es)Phongsisay Vongsavanh
ResumoCampylobacter jejuni causes gastroenteritis and Guillain-Barré syndrome. Host immunity plays an important role in the disease pathogenesis; however, little is known about the immune receptors for C. jejuni. We report here that C. jejuni targets C-type lectin (SIGNR1, SIGNR3) and immunoglobulin-like receptors (TREM2, TREM3, LMIR5, LMIR8). Among these, C. jejuni interacted preferentially with LMIR5, which was selected for further verification using reporter cells. LMIR5 ligation by C. jejuni activated transcriptional factor NFAT through adaptor protein DAP12. Furthermore, LMIR5 activators were identified as protein components, RNA-associated proteins, and 150-kDa high-molecular-weight glycoconjugates. This finding discloses potential receptors that might link C. jejuni to immunopathology.
Palavras-ChaveCampylobacter jejuni, Immune responses, LMIR5/CD300b, Receptor
ImprentaMolecular Immunology, v. 63, n. 2, p. 574-578, 2015
Identificador do Objeto Digital10.1016/j.molimm.2014.07.024
DescritoresGuillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - RNA ; Guillain-Barre Syndrome - Immunopathology ; Guillain-Barre Syndrome - Immunology
Data de Publicação:2015
