Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients.

Autor(es): Kawamura Nobutoshi,Piao Hua,Minohara Motozumi,Matsushita Takuya,Kusunoki Susumu,Matsumoto Hiroshi,Ikenaka Kazuhiro,Mizunoe Yoshimitsu,Kira Jun-ichi

Resumo: Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

Imprenta: Journal of Neuroimmunology, v. 240-241, p. 74-78, 2011

Identificador do objeto digital: 10.1016/j.jneuroim.2011.09.004

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - DNA ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2011