Axonal Guillain-Barré syndrome.

Autor(es): Feasby T E

Resumo: The issue of axonal" Guillain-Barré syndrome (GBS) remains controversial. Supportive evidence comes from pathological examination of peripheral nerves in 4 extreme cases of GBS 17-29 days after onset which showed severe axonal degeneration without inflammatory-demyelination. It has been suggested that inflammatory-demyelination may have been missed. This is difficult to disprove but it seems unlikely, given the known correlation between the severity of axonal degeneration and inflammation/demyelination in the experimental model of GBS, experimental allergic neuritis (EAN). Electrically inexcitable nerves in GBS may reflect axonal degeneration, terminal demyelination or both. This finding proved to be a sign of poor prognosis in 19 of 27 (70%) patients, although a good outcome occurred in some cases."

Imprenta: Muscle & Nerve, v. 17, n. 6, p. 678-679, 1994

Identificador do objeto digital: 10.1002/mus.880170618

Descritores: Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Inflammation ; Guillain-Barre Syndrome - Clinical examination

Data de publicação: 1994