Autoantibodies to GM1 and GQ1b? are not biological markers of Alzheimer's disease.

Autor(es): Miura Yumako,Miyaji Kazuki,Chai Yuek Ling,Chen Christopher L H,Lai Mitchell K P,Yuki Nobuhiro

Resumo: A few studies have reported the association of autoantibodies to GM1 or GQ1b? with Alzheimer's disease (AD) or vascular dementia. Here we investigated whether patients with AD or vascular dementia had high titers of the anti-ganglioside antibodies. Sera were obtained from patients with AD (n = 22), vascular dementia (n = 14), Guillain-Barré syndrome, and multifocal motor neuropathy as well as normal controls. Enzyme-linked immunosorbent assay showed titers of IgG and IgM anti-GM1, anti-GQ1b?, and anti-GT1a? antibodies did not differ among AD, vascular dementia, and normal controls, and being remarkably lower than those in Guillain-Barré syndrome and multifocal motor neuropathy. The anti-ganglioside antibodies are not biological markers of AD.

Palavras-Chave: Alzheimer's disease, anti-ganglioside antibody, biological marker, ganglioside

Imprenta: Journal of Alzheimer's Disease : JAD, v. 42, n. 4, p. 1165-1169, 2014

Identificador do objeto digital: 10.3233/JAD-140474

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2014