Association of anti-GM2 antibodies in Guillain-Barré syndrome with acute cytomegalovirus infection.
Autor(es): Irie S,Saito T,Nakamura K,Kanazawa N,Ogino M,Nukazawa T,Ito H,Tamai Y,Kowa H
Resumo: We examined serum anti-cytomegalovirus (CMV) and anti-ganglioside antibodies by ELISA in 51 patients with Guillain-Barré syndrome (GBS), and titers were compared with those from 47 normal and 74 disease controls. Three GBS patients with IgM anti-CMV antibodies had high titers of IgM and IgG anti-GM2 antibodies. The other GBS patients without IgM anti-CMV antibodies, and the normal and disease controls except one of 6 non-GBS patients with acute CMV infections had no anti-GM2 antibodies. The titers of anti-GM2 antibodies decreased on absorption with CMV-infected cells. These findings suggest that anti-GM2 antibodies are associated with acute CMV infections in GBS patients.
Imprenta: Journal of Neuroimmunology, v. 68, n. 1-2, p. 19-26, 1996
Identificador do objeto digital: 10.1016/0165-5728(96)00059-8
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Molecular Structure ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - virus ; Guillain-Barre Syndrome - Immunology
Data de publicação: 1996
