Anti-GQ1b IgG antibody is associated with ataxia as well as ophthalmoplegia.

Autor(es): Kusunoki S,Chiba A,Kanazawa I

Resumo: Close association between the increase in anti-GQ1b immunoglobulin G (IgG) antibody and ophthalmoplegia in Miller Fisher syndrome (MFS) and Guillain-Barré syndrome (GBS) has been reported. We investigated whether anti-GQ1b IgG antibody also is associated with ataxia, another of the MFS triad. Of 149 patients who had anti-GQ1b IgG antibody without profound weakness, 144 showed ophthalmoplegia (120 showed both ophthalmoplegia and ataxia; 24, ophthalmoplegia without ataxia). In contrast, five showed ataxia without ophthalmoplegia. Some large neurons of the dorsal root ganglia were immunostained with anti-GQ1b monoclonal antibody. Anti-GQ1b IgG antibody may thus be associated with ataxia as well as ophthalmoplegia. Ataxia may be due to its binding to a subset of primary sensory neurons.

Imprenta: Muscle & Nerve, v. 22, n. 8, p. 1071-1074, 1999

Identificador do objeto digital: 10.1002/(SICI)1097-4598(199908)22:8<1071::AID-MUS10>3.0.CO;2-0

Descritores: Guillain-Barre Syndrome - Biochemistry ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 1999