Anti-GQ1b antibody syndrome presenting as acute isolated bilateral ophthalmoplegia: Report on two patients and review of the literature.

Autor(es): Guisset François,Ferreiro Christine,Voets Serge,Sellier Julie,Debaugnies France,Corazza Francis,Deconinck Nicolas,Prigogine Cynthia

Resumo: Miller Fisher syndrome (MFS) is an acute polyradiculoneuritis regarded as an uncommon clinical variant of Guillain-Barré syndrome (GBS). MFS is characterized by the acute onset of the clinical triad of ophthalmoplegia, cereballar ataxia and areflexia. Atypical forms of MFS presenting as isolated ophthalmoplegia without ataxia have been rarely described, mostly in adults. We present two cases of acute isolated bilateral ophthalmoplegia in childhood, both occurring shortly after Campylobacter jejuni enteritis. Serum analysis of anti-ganglioside antibodies revealed elevated levels of anti-GQ1b IgG and IgM. We observed in both children complete spontaneous resolution several weeks after onset. The cases of the two patients confirm the rare but possible occurrence of atypical MFS in young children a few weeks after gastrointestinal infection. Identification of high levels of anti-GQ1b antibodies in the serum may help confirm the diagnosis of MFS even when its clinical presentation is incomplete.

Palavras-Chave: Acute ophthalmoplegia, Anti-GQ1b antibody, Atypical Miller Fisher syndrome, Children

Imprenta: European Journal of Paediatric Neurology, v. 20, n. 3, p. 439-443, 2016

Identificador do objeto digital: 10.1016/j.ejpn.2016.02.002

Descritores: Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2016