Anti-GM1b IgG antibody is associated with acute motor axonal neuropathy and Campylobacter jejuni infection.
Autor(es): Ogawara Kazue,Kuwabara Satoshi,Koga Michiaki,Mori Masahiro,Yuki Nobuhiro,Hattori Takamichi
Resumo: Anti-GM1 and anti-GM1b antibodies are frequently present in patients with Guillain-Barré syndrome (GBS) and accordingly, the two antibodies often coexist in the same patient. In order to study clinical and laboratory features of anti-GM1b-positive GBS, we analyzed the data of patients with anti-GM1b IgG antibody but no anti-GM1 IgG antibody. Of 86 consecutive patients, 10 had anti-GM1b antibody alone and frequently had acute motor axonal neuropathy (AMAN, 80%) and Campylobacter jejuni infection (60%). Of 10 patients with anti-GM1 antibody alone, four had AMAN, and two had C. jejuni infection. These results showed that GM1b could be a target molecule of autoantibody in the AMAN form of GBS subsequent to C. jejuni infection.
Imprenta: Journal of the Neurological Sciences, v. 210, n. 1-2, p. 41-45, 2003
Identificador do objeto digital: 10.1016/S0022-510X(03)00013-3
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2003
