Anti-Gal-C antibody in autoimmune neuropathies subsequent to mycoplasma infection.

Autor(es): Kusunoki S,Chiba A,Hitoshi S,Takizawa H,Kanazawa I

Resumo: Four of 82 patients with Guillain-Barré syndrome (GBS) and 1 of 12 with multifocal motor neuropathy (MMN), who previously had had Mycoplasma pneumoniae infections, had serum antibody to galactocerebroside (Gal-C). Two patients with GBS without mycoplasma infection also had anti-Gal-C antibody, whereas none of the normal or the disease controls had it. As Gal-C is a major glycolipid antigen in myelin, anti-Gal-C antibody may function in the pathogenesis of autoimmune demyelinative neuropathies. Mycoplasma pneumoniae appears to be an important preceding infectious agent in autoimmune neuropathies with anti-Gal-C antibody.

Imprenta: Muscle & Nerve, v. 18, n. 4, p. 409-413, 1995

Identificador do objeto digital: 10.1002/mus.880180407

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Infectious diseases ; Guillain-Barre Syndrome - Immunology

Data de publicação: 1995