Anti-Gal-C antibodies in GBS subsequent to mycoplasma infection: evidence of molecular mimicry.
Autor(es): Kusunoki S,Shiina M,Kanazawa I
Resumo: The authors previously reported the presence of antibody against galactocerebroside (Gal-C) in sera from patients with Guillain-Barré syndrome subsequent to Mycoplasma pneumoniae infection. Anti-Gal-C antibody activities in these sera were inhibited specifically by the M. pneumoniae reagent. A rabbit anti-Gal-C antibody recognized several glycolipids in M. pneumoniae. These data show that a Gal-C-like structure is present in M. pneumoniae, indicative of molecular mimicry between a major myelin glycolipid, Gal-C, and M. pneumoniae.
Imprenta: Neurology, v. 57, n. 4, p. 736-738, 2001
Identificador do objeto digital: 10.1212/WNL.57.4.736
Descritores: Guillain-Barre Syndrome - Molecular Structure ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2001
