Antibody to human T-lymphotropic virus in a patient with Guillain-Barré syndrome (case report)

Autor(es): Nakauchi C M,Linhares A C,Gomes M L,Maruyama K,Kanzaki L I,Azevedo V N


Resumo: Serum sample obtained from a male, 12 year old patient suffering from Guillain-Barré syndrome (GBS) was positive for human T-lymphotropic virus (HTLV-I) antibody by the enzyme-linked immunosorbent assay (ELISA) and the Western Blot analysis (WB). Attempts to isolate enteroviruses (including poliovirus) from faecal material in both tissue culture and suckling mice were unsuccessful; in addition, acute and convalescent paired serum samples did not show any evidence of recent poliovirus infection when tested against the three serotypes. Specific tests for detection of Epstein-Barr virus infection were not performed; however, the Paul-Bunnel test yielded negative results. ELISA for detection of anti-cytomegalovirus IgM was also negative. The concomitant occurrence of either adult T cell leukemia (ATL) or lymphoma was not recorded in this case.


Imprenta: Revista do Instituto de Medicina Tropical de Sa?o Paulo, v. 33, n. 4, p. 329-331, 1991


Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - virus ; Guillain-Barre Syndrome - Immunology


Data de publicação: 1991