An antibody to VacA of Helicobacter pylori in the CSF of patients with Miller-Fisher syndrome.

Autor(es): Chiba S,Sugiyama T,Yonekura K,Tanaka S,Matsumoto H,Fujii N,Yokota S,Hirayama T

Resumo: The authors examined antibodies against native vacuolating cytotoxin (VacA) of Helicobacter pylori in CSF from 12 patients with Miller-Fisher syndrome (MFS). The VacA protein was separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting analysis was carried out. Eight of 12 MFS patients had a specific immunoglobulin G antibody against VacA in the CSF. There is sequence homology between VacA and some membrane ion transport proteins, raising the possibility that A-VacA-Ab involves the ion channels in the node of Ranvier in some patients with MFS.

Imprenta: Neurology, v. 63, n. 11, p. 2184-2186, 2004

Identificador do objeto digital: 10.1212/01.WNL.0000145705.82690.04

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2004