Autor(es): Koga M,Koike S,Hirata K,Yuki N

Resumo: Haemophilus influenzae is considered a causative agent of Guillain-Barré syndrome (GBS) and Fisher syndrome, but the frequency of this infection in GBS is controversial. To determine whether isolation of H influenzae indicates it is a causative agent in GBS and Fisher syndrome. Four (15%) of 27 patients with GBS and Fisher syndrome in whom H influenzae was isolated were also seropositive for Campylobacter jejuni. Antiganglioside IgG antibodies in these four patients did not cross react with their H influenzae lipo-oligosaccharides, whereas antiganglioside antibodies in the four patients with positive serology for H influenzae did. The findings suggest that H influenzae isolation is not always indicative of the causative agent in these syndromes and that tests for other infections should be made, even in cases of positive culture.

Imprenta: Journal of Neurology, Neurosurgery, and Psychiatry, v. 76, n. 12, p. 1736-1738, 2005

Identificador do objeto digital: 10.1136/jnnp.2005.065359

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Serology

Data de publicação: 2005

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