Autor(es)Amit R,Glick B,Itzchak Y,Dgani Y,Meyeir S

ResumoWe present a second case in which Guillain-Barré syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) appeared simultaneously, both in acute and fulminant form. The patient, a 10-year-old girl, presented with acute onset of coma and flaccid, are-flexic quadriparesis. The elevated CSF protein levels and delayed F waves fulfilled the criteria of GBS and an MRI study revealed extensive multifocal demyelination compatible with a diagnosis of ADEM. Prompt clinical response followed by complete recovery was achieved by treatment with corticosteroids. It is suggested that acute severe combined demyelination might constitute a separate entity in which the demyelinating process, involving simultaneously the central and the peripheral nervous systems, indicates immune response against a component of the myelin of one system carrying cross-antigenicity with the other.

ImprentaChild's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery, v. 8, n. 6, p. 354-356, 1992

DescritoresGuillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Pathogenesis

Data de Publicação:1992