Acute inflammatory demyelinating polyradiculoneuropathy in a patient receiving oxaliplatin-based chemotherapy.
Autor(es): Yoon Ju Young,Nam Tai Seung,Kim Myeong Kyu,Hwang Jun Eul,Shim Hyun-Jeong,Cho Sang Hee,Chung Ik Joo,Bae Woo Kyun
Resumo: We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomography. He was treated with 5-fluorouracil, leucovorin and oxaliplatin (100 mg/m(2)). After eight cycles of treatment and a cumulative oxaliplatin dose of 780 mg/m(2), he developed an unsteady gait, dysphagia, weakness of both the upper and lower limbs and impairment of all sensory modalities. Nerve conduction studies confirmed the diagnosis of AIDP. Immunoglobulin G i.v. was administered for 5 days but the neurological deficits of both his upper and lower limbs did not improve. This case highlights unusual peripheral nervous system manifestations in a patient who received chemotherapy with oxaliplatin.
Imprenta: Asia-Pacific Journal of Clinical Oncology, v. 8, n. 2, p. 201-204, 2012
Identificador do objeto digital: 10.1111/j.1743-7563.2011.01515.x
Descritores: Guillain-Barre Syndrome - Pathogenesis
Data de publicação: 2012
