A transient state model for analysing ventilatory status in a randomized clinical trial.

Autor(es): Jais J P,Chastang C,Raphael J C

Resumo: We designed a randomized clinical trial to determine the efficacy of plasma exchange in Guillain-Barré syndrome, an acute neurological disease leading to paralysis in previously healthy subjects. Some patients require temporary mechanical ventilation during the course of the disease. Ventilatory status was analysed using a three-state model with a transient state defined by use of temporary mechanical ventilation, and the probability of being mechanically ventilated modelled as a function of time since randomization. The plot of this function reflects the effect of plasma exchange on ventilatory status showing that fewer plasma-exchanged patients than controls required ventilatory assistance and that the duration of assistance was shorter. Similar functions can be used in a more general framework when the response criterion includes a transient state.

Imprenta: Statistics in Medicine, v. 6, n. 7, p. 795-803, 1987

Identificador do objeto digital: 10.1002/sim.4780060710

Descritores: Guillain-Barre Syndrome - Public health

Data de publicação: 1987