A fatal case of West Nile virus infection in a bone marrow transplant recipient.

Autor(es): Hiatt Bradley; DesJardin Lucy; Carter Thomas; Gingrich Roger; Thompson Curt; de Magalhaes-Silverman Margarida

Resumo: West Nile virus (WNV) can cause severe, potentially fatal neurological illnesses, which include encephalitis, meningitis, Guillain-Barré syndrome, and anterior myelitis. Because of the short viremic phase, WNV infection is most commonly diagnosed by detection of immunoglobulin M antibody to WNV in serum or cerebrospinal fluid (CSF). We describe a patient with T cell lymphoma who had undergone a T cell-depleted bone marrow transplantation and developed fatal WNV infection. The results of serological tests of blood samples and of CSF tests were negative. Diagnosis was made postmortem by a positive result of reverse-transcriptase polymerase chain reaction (ABI 7700; TaqMan) for WNV in stored CSF and serum samples.

Imprenta: Clinical Infectious Diseases, v. 37, n. 9, p. 129-131, 2003

Identificador do objeto digital: 10.1086/378891

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Flaviviridae ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Serology ; Guillain-Barre Syndrome - Viral infections ; Guillain-Barre Syndrome - RT-PCR ; Guillain-Barre Syndrome - Serological diagnosis ; Guillain-Barre Syndrome - Virus ; Guillain-Barre Syndrome - Epidemiology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2003