The effect of treatment with crotapotin on the evolution of experimental autoimmune neuritis induced in Lewis rats

Autor(es): Castro Fabiano R,Farias Alessandro S,Proença Patricia L F,de La Hoz Cristiane,Langone Francesco,Oliveira Elaine C,Toyama Marcos H,Marangoni Sergio,Santos Leonilda M B

Resumo: Biomedical research in which venom components are being investigated for their potential as novel therapeutic agents has emerged as an interesting option. Crotapotin, which is purified from the venom of the rattlesnake Crotalus durissus terrificus, has been described as an anti-inflammatory agent that acts on the innate arm of the immune response. Here we have demonstrated that intraperitoneal administration of crotapotin significantly reduces the severity of experimental autoimmune neuritis (EAN), an experimental model for Guillain-Barré syndrome. The reduction of the severity of the disease is associated with a reduction in the mononuclear cells infiltrating the sciatic nerve and a significant decrease in the lymphocyte proliferative response to neuritogenic peptide.

Palavras-Chave: Demyelination; T-cell activation; Experimental autoimmune neuritis; Guillain-barré syndrome

Imprenta: Toxicon, v. 49, n. 3, p. 299-305, 2007

Identificador do objeto digital: 10.1016/j.toxicon.2006.09.028

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2007