Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes.
Autor(es): Goto H.; Matsuo H.; Nakane S.; Izumoto H.; Fukudome T.; Kambara C.; Shibuya N.
Resumo: Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immunoadsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.
Imprenta: Therapeutic Apheresis, v. 5, n. 6, p. 494-496, 2001
Identificador do objeto digital: 10.1046/j.1526-0968.2001.00386.x
Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology
Data de publicação: 2001
