Serum tumor necrosis factor-alpha in Guillain-Barré syndrome and its relation to plasma exchange

Autor(es): Reuben Sheela,Mathai Annamma,George Sumi M,Nair M D,Radhakrishnan V V

Resumo: To correlate the serum tumor necrosis factor-alpha (TNFalpha) concentrations before, during and following plasma exchange in patients with Guillain-Barré syndrome (GBS). In this prospective study, 21 GBS patients were selected. Patients in clinical stages III to V were subjected to plasma exchange. The control group included equal numbers of age-matched patients with other neurological diseases and healthy voluntary blood donors. A sandwich ELISA method was applied to estimate serum TNFalpha concentrations in test and control groups. Twelve GBS patients had elevated serum TNFalpha levels that ranged between 74 and 182 pg/mL. All 12 GBS patients showed a steady decrease in the TNFalpha concentration following plasma exchange and also showed a positive correlation with neurological recovery. We conclude that serum TNFalpha concentrations are elevated in 57.1% of GBS patients and TNFalpha level decreases following plasma exchange.

Imprenta: The Neurologist, v. 8, n. 1, p. 47-50, 2002

Descritores: Guillain-Barre Syndrome - Cytopathology

Data de publicação: 2002