Pathophysiology and diagnosis of Guillain-Barré syndrome - challenges and needs.
Autor(es): Dash Sambit; Pai Aparna R.; Kamath Ullas; Rao Pragna
Resumo: Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. Both sensory and autonomic nerve involvement is seen. GBS has various subtypes that vary in their pathophysiology. The pathogenesis involves an immune response triggered by a preceding event which may be an infection, immunisation or surgical procedure. Clinical diagnosis has been largely the primary diagnosing criterion for GBS along with electrodiagnosis, which has several pitfalls and is supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve Conduction Studies. Measurement of anti-ganglioside antibodies is also an effective tool in its diagnosis. Further understanding of pathophysiology and better diagnostic methods are required for better management of GBS.
Palavras-Chave: Campylobacter jejuni, anti-ganglioside antibodies, autoimmunity, electrodiagnosis, molecular mimicry
Imprenta: The International Journal of Neuroscience, v. 125, n. 4, p. 235-240, 2015
Identificador do objeto digital: 10.3109/00207454.2014.913588
Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Biochemistry ; Guillain-Barre Syndrome - Cytopathology ; Guillain-Barre Syndrome - Immune response ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Autoimmunity ; Guillain-Barre Syndrome - Molecular methods ; Guillain-Barre Syndrome - Molecular screening ; Guillain-Barre Syndrome - Epidemiology
Data de publicação: 2015
