Hypocretin-1 (orexin-A) concentrations in cerebrospinal fluid are low in patients with Guillain-Barré syndrome.

Autor(es): Kanbayashi Takashi; Ishiguro Hideaki; Aizawa Rika; Saito Yasushi; Ogawa Yuriko; Abe Masahito; Hirota Kouichi; Nishino Seiji; Shimizu Tetsuo

Resumo: It is reported that cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) concentrations in patients with narcolepsy are significantly low. Human narcolepsy is also known to be closely associated with a specific human histocompatibility leukocyte antigen (HLA), suggesting that autoimmunity is involved in the pathophysiology of the disease. Thus, it is important to know whether hypocretin changes are found in definite neuroimmunological diseases such as multiple sclerosis and Guillain-Barré syndrome (GBS). The results of the present study indicate that some patients with GBS have lower levels of CSF hypocretin-1.

Imprenta: Psychiatry and Clinical Neurosciences, v. 56, n. 3, p. 273-274, 2002

Identificador do objeto digital: 10.1046/j.1440-1819.2002.00974.x

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Autoimmunity ; Guillain-Barre Syndrome - Immunology ; Guillain-Barre Syndrome - Public health

Data de publicação: 2002