Autor(es): Canpolat Mehmet,Kumandas Sefer,Yikilmaz Ali,Gumus Hakan,Koseoglu Emel,Poyrazo?lu Hatice Gamze,Kose Mehmet,Per Huseyin

Resumo: Guillain-Barré syndrome is a rapidly progressive symmetrical muscle weakness associated with acute inflammatory disease. Transverse myelitis (TM) is the inflammation of the spinal cord characterized by rapidly evolving muscle weakness in the lower extremities, defects in sensory level and sphincter dysfunction. Guillain-Barré syndrome, and TM association occurs very rarely in childhood. A 7-year-old girl presented with complaints of neck pain, spout-style vomiting, cough, shortness of breath, and acute paraparesis with sensory and sphincter disturbance. The patient was intubated because of increased respiratory distress. A positive direct fluorescein antigen test in bronchoalveolar lavage confirmed Legionella pneumophila infection. Imaging and neurophysiologic studies were diagnostic for TM with acute motor and sensory axonal neuropathy. She was treated with a combination of high-dose methylprednisolone and intravenous immunoglobulins, and we observed incomplete recovery. The presented case is the first child with concomitant TM and acute motor and sensory axonal neuropathy related to L. pneumophila infection.

Palavras-Chave: Legionella pneumophila; Acute motor and sensory axonal neuropathy; Child; Immune modulation; Transverse myelitis

Imprenta: Pediatrics International : Official Journal of the Japan Pediatric Society, v. 55, n. 6, p. 778-782, 2013

Identificador do objeto digital: 10.1111/ped.12126

Descritores: Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Inflammation

Data de publicação: 2013

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