Guillain-Barré syndrome.
Autor(es): Rosen Beth A.
Resumo: Based on strong research evidence, in countries where poliomyelitis has been eliminated, GBS is the most common cause of acquired paralysis in children. (9) - Based on strong research evidence, GBS describes a spectrum of disorders caused by an autoimmune reaction against peripheral nerve components, including the myelin sheath and the axon. (10)(11) - Based on strong research evidence, GBS usually is preceded by a bacterial or viral infection, less likely by vaccination in the 1 to 4 weeks before onset. The strongest relationship is with infection by C jejuni. (12)(13) - Based on strong research evidence, GBS in children most often presents with symmetrical ascending paralysis, diminished or absent reflexes, and often severe pain. Pain may lead to a delay in diagnosis. (2) (3)(9)(14) - Based on strong research evidence, the progressive phase peaks in 7 to 14 days and can lead to various levels of weakness, from abnormal gait to total paralysis, cranial nerve weakness, pain, respiratory compromise, and autonomic instability. (2) - Based on some research evidence and consensus, children require hospitalization and often intensive care until their condition stabilizes because of significant risk of respiratory compromise and autonomic instability. (15) - Based on strong research evidence in adults and some research evidence in children, IVIG and plasma exchange hasten recovery from GBS in patients with impaired ability to ambulate. (4)(6) - Based primarily on consensus, IVIG is the treatment of choice in children with GBS. (6)(9)(15) - Based on strong research evidence, the prognosis for full functional recovery in childhood GBS is excellent. (2)(8)(9).
Imprenta: Pediatrics in Review / American Academy of Pediatrics, v. 33, n. 4, p. 164-170, 2012
Identificador do objeto digital: 10.1542/pir.33-4-164
Descritores: Guillain-Barre Syndrome - Epidemiology
Data de publicação: 2012
