Human alpha tumor necrosis factor does not damage cultures containing rat Schwann cells and sensory neurons.

Autor(es): Mithen F. A.; Colburn S.; Birchem R.

Resumo: The effects of recombinant human alpha tumor necrosis factor (alpha-TNF) were compared with those of cytotoxic serum from patients with the acute Guillain-Barré syndrome (GBS) in myelinated cultures containing only rat Schwann cells and dorsal root ganglion neurons. Alpha-TNF did not damage rat peripheral nervous system tissue in culture. These observations suggest that alpha-TNF is not responsible for the cytotoxic activity of acute GBS serum in culture.

Imprenta: Neuroscience Research, v. 9, n. 1, p. 59-63, 1990

Identificador do objeto digital: 10.1016/0168-0102(90)90046-H

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines

Data de publicação: 1990