Reactivity with neural cell adhesion molecules in sera from patients with demyelinating diseases.

Autor(es): Poltorak M.; Steck A. J.; Schachner M.

Resumo: Sera from 5 patients with IgM gammopathy and peripheral neuropathy reacted strongly by a sensitive immunospot enzyme-linked immunosorbent assay test with the myelin-associated glycoprotein (MAG) purified from human and bovine brains and the novel neural cell adhesion molecule J1 and associated glycoproteins from human brain. Two other members of the L2/HNK-1 family of cell adhesion molecules, the L1 glycoprotein and the neural cell adhesion molecule N-CAM, are not recognized significantly more strongly by these sera than by sera from patients with multiple sclerosis. Sera from patients with Guillain-Barré syndrome and amyotrophic lateral sclerosis and from healthy humans did not react with any of the glycoproteins tested at the serum concentrations used.

Imprenta: Neuroscience Letters, v. 65, n. 2, p. 199-203, 1986

Identificador do objeto digital: 10.1016/0304-3940(86)90304-6

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Antibodies ; Guillain-Barre Syndrome - Immunology

Data de publicação: 1986