MMP-9 correlates with electrophysiologic abnormalities in Guillain-Barré syndrome.

Autor(es): Sharshar T.; Durand M-C.; Lefaucheur J-P.; Lofaso F,Raphaël J-C.; Gherardi R K.; Créange A.

Resumo: To investigate the role of MMP-9 in Guillain-Barré syndrome, the authors correlated electrophysiologic abnormalities and MMP-9 plasma levels in a series of 21 patients. MMP-9 plasma levels were higher in the demyelinating group than in the nondemyelinating group, and in patients with high CSF protein level. Increase of MMP-9 circulating levels correlated with the increase of F waves latencies, reduction of CMAP amplitude, and decrease of nerve conduction velocities. Circulating MMP-9 may contribute to the peripheral nerve dysfunction of demyelinating Guillain-Barré syndrome.

Imprenta: Neurology, v. 59, n. 10, p. 1649-1651, 2002

Identificador do objeto digital: 10.1212/01.WNL.0000033799.58866.7A

Descritores: Guillain-Barre Syndrome - Biosynthesis ; Guillain-Barre Syndrome - Proteins

Data de publicação: 2002