IFN-beta decreases adhesion and transmigration capacities of lymphocytes in Guillain-Barré syndrome.

Autor(es): Créange A.; Chazaud B; Plonquet A.; Sharshar T.; Poron F.; Sonnet C.; Raphaël J. C.; Gherardi R. K.

Resumo: The adhesion capacities, transmigration capacities, and integrin expression of lymphocytes from patients with Guillain-Barré syndrome incubated with interferon-beta were studied. Interferon-beta induced a dose-dependent inhibition of lymphocyte adhesion to recombinant vascular adhesion molecule-1 (p < 0.0001) and recombinant intercellular adhesion molecule-1 (rICAM-1) (p < 0.01) without modulation of very late activation molecule-4 and lymphocyte function-associated antigen-1 expressions and a dose-dependent decrease of lymphocyte transmigration across fibronectin (p < 0.0001). Inhibition of adhesion to rICAM-1 was similar after long (18 hours) or short (5 minutes) incubation time. These results support the potential therapeutic benefit of interferon-beta in Guillain-Barré syndrome.

Imprenta: Neurology, v. 57, n. 9, p. 1704-1706, 2001

Identificador do objeto digital: 10.?1212/?WNL.?57.?9.?1704

Descritores: Guillain-Barre Syndrome - Cell ; Guillain-Barre Syndrome - Pathogenesis ; Guillain-Barre Syndrome - Proteins ; Guillain-Barre Syndrome - Cytokines ; Guillain-Barre Syndrome - Immunology

Data de publicação: 2001